Endocrine Abstracts

Case report: We present the case of a patient with somatotroph adenoma combined with neuronal choristoma Pituitary Adenoma Neuronal CHoristoma (PANCH). A female patient, 44 years of age, manifested with acromegaly type features since 1993, while mentioning also headaches, amenorrhea, and peripheral type visual disturbances since 1997. The clinical examination revealed an obese woman with typical acromegalic features. The laboratory evaluation before pituitary surgery showed a ...

The use of LC–MS/MS quantitative methods in clinical and research laboratories is becoming a well established reality that may overcome specificity and accuracy limits of immunoassays. Nevertheless, among different LC–MS/MS methods an agreement on the values that are to be considered normal or pathologic has not been reached yet, and this is mainly due to differences in LC–MS/MS methods, to the poor or absent availability of reference material and to the selecti...

Interrelationships between HPA axis and sleep architecture are well documented and increased glucocorticoid levels seem associated with quantitative and qualitative sleep disruptions. The knowledge about sleep parameters in chronic hypercortisolism in humans is scanty. Our aim was to evaluate sleep efficiency in patients with Cushing’s syndrome (CS) at time of diagnosis, without ongoing specific therapy, using wrist actigraphy, a methodology that provides good estimations...

A number of publications recently provided measurements of plasma ECs by liquid chromatography–tandem mass spectrometry (LC–MS/MS), however the reported circulating levels in normal subjects are scattered in a very wide range of concentrations. A quantitative LC–MS/MS method for anandamide (AEA), palmitoylethanolamide (PEA), oleoylethanolamyde (OEA) and 2arachidonoyl-glycerol (2AG), chromatographically resolved by its inactive isomer 1AG, was validated in house....